Fate and Effects of Cytostatic Pharmaceuticals in the Environment and Identification of Biomarkers for an Improved Risk Assessment on Environmental Exposure – CytoThreat

Leading organisations:
National Institute of Biology (Slovenia), Výskumného ústavu vodného hospodárstva (Slovakia), Medical University of Vienna (Austria), Szent István University (Hungary), Second University of Naples (Italy), Council for Scientific Research (Spain), Institute for Medical Research and Occupational Health (Croatia), Institute for Multidisciplinary Research (Serbia), and RR & CO. Knowledge Centre Ltd. (Slovenia)


Geographic Area:
Central Europe Southern Europe Western Europe


To assess the risks of pharmaceuticals released in the environment, focusing on cytostatic drugs.

Target audience:
Health Professionals, Hospitals/health system stakeholders, Local governments, National/Local decision and policy makers, Pharmaceutical manufacturers, Scientists, and Water/waste service providers

Area of interest:
Occurrence of pharmaceuticals in the environment, Pharmaceutical manufacturing, Pharmaceutical waste & waste management, Risks to ecosystems, Wastewater, and Water treatment technologies


1) To develop new analytical methods for assessment of the occurrence and fate of cytostatic pharmaceuticals, their metabolites and transformation products in water treatment systems and in the environment, 2) To explore potential delayed and irreversible effects of cytostatic pharmaceuticals at environmentally relevant concentrations in aquatic experimental models, and compare the data to those obtained in human experimental models, 3) To explore combined effects of mixtures of cytostatic pharmaceuticals, their excreted metabolites and transformation products formed in the environment and/or wastewater treatment, 4) To develop, based on the obtained results, guidance on how to improve the environmental and human risk assessment of cytostatics released into the environment.

Communication material:

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HCWH Europe gratefully acknowledges the financial support of the European Commission (EC)’s LIFE+ programme, the Federal Ministry for the Environment, Nature Conservation, and Nuclear Safety (BMU) Germany, and the German Environment Agency (UBA). HCWH Europe is solely responsible for the content of this project and related materials. The views expressed do not reflect the official views of the EC, BMU, or UBA.