Project has two parts:
Part 1: a literature review conducted in 2013, and
Part 2: effect-based in vivo and in vitro-studies which started in March 2014 and ended in February 2016
Part 1: To gain an overview on recently published literature on pharmaceutical effects and accumulation, as well as possibilities for the monitoring of pharmaceuticals with in vivo-systems.
Part 2: To develop new, mode-of-action based in vitro systems, which can be used to detect specific pharmaceutical classes as a whole.
– Creation of a database on published effects of various pharmaceuticals of high priority
– Creation of literature databases containing all relevant publications
– A system for the monitoring of non-steroidal anti-inflammatory drugs (NSAIDs), was designed (Steinbeis Transfer Center Mannheim)
– In vivo studies on effects in trout (University of Tübingen), gammarids (GWT) and annelids (University of Frankfurt )
– Chemical analyses in water and biota (TZW)
- From theory to reality – Evaluation of suitable organisms and test systems for the biomonitoring of pharmaceuticals. Part I: Literature review
- EFF-Pharm: Effects of pharmaceuticals (nonsteroidal anti-inflammatory drugs and beta-blockers) in fish and invertebrates and their detection by newly developed in vitro-bioassays. Final Report.
HCWH Europe gratefully acknowledges the financial support of the European Commission (EC)’s LIFE+ programme, the Federal Ministry for the Environment, Nature Conservation, and Nuclear Safety (BMU) Germany, and the German Environment Agency (UBA). HCWH Europe is solely responsible for the content of this project and related materials. The views expressed do not reflect the official views of the EC, BMU, or UBA.